Revista de Obstetricia y Ginecología de Venezuela
Print version ISSN 0048-7732
RIVAS, Aleida M; GONZALEZ, Julio C; GUEVARA, Mary C and DAVILA, Solange G. Alteraciones clínico-metabólicas en mujeres con diabetes gestacional previa. Rev Obstet Ginecol Venez [online]. 2010, vol.70, n.1, pp. 18-23. ISSN 0048-7732.
Objective: To know the frequency of diabetes and other cardiovascular risk factors in women with previous gestational diabetes mellitus (GDM). Methods: 92 women with previous GDM, without diagnosis of diabetes, who underwent initial or annual postpartum diabetes screening during 2008, were assessed. Blood pressure, abdominal circumference and body mass index were measured. They were tested for an oral glucose tolerance test (OGTT) and determination of plasma insulin and lipid levels. Metabolic syndrome (MS) was diagnosed according ATP III criteria and the HOMA-R model was used for the insulin resistance index calculation. Students t test was used for variables association. Results: The average age was 34.7 ± 6.6 years and postpartum period, 3.5 ± 2.6 years. 8.7% was diagnosed with diabetes, 32.6 % with impaired glucose tolerance and 12.0 % with impaired fasting glucose. 62.1 % showed abdominal obesity, 62.5 % presented some type of dyslipidemia and 23.8 %, high blood pressure. 46.4 % met the criteria for MS, and 29.6 % showed a HOMA-R Index > 2.5. Abdominal circumference, body mass index, blood pressure, triglycerides, basal glucose, 2-h post-load glucose and 2-h post-load insulin values were higher (P< 0.05) in women with abnormal glucose tolerance than those with normal glucose tolerance. Conclusions: Women with previous GDM show a high frequency of clinical and metabolic abnormalities that point towards a potential increase of cardiovascular risk in a relatively young population.
Keywords : Previous gestational diabetes; Metabolic syndrome; Postpartum diabetes screening.